Switching to Tresiba(R) is Highly Cost-effective and Cost-saving in a Real-world Setting

Food and Healthcare Press Releases Monday November 6, 2017 15:45
GLASGOW, Scotland--6 Nov--PRNewswire/InfoQuest
Poster Presentation PDB27

A new analysis of real-world data has shown that switching to Tresiba(R) (insulin degludec) is highly cost-effective and cost-saving for the treatment of type 1 and type 2 diabetes, respectively.[1] The analysis was presented today at the International Society for Pharmacoeconomics and Outcomes Research (ISPOR 2017) 20th Annual European Congress.

Tresiba(R) remained cost-effective even after excluding key benefits associated with switching to Tresiba(R) such as reductions in hypoglycaemia (low blood sugar levels) and the use of health system resources in a calculation based on a treatment period of one year. When estimating the lifetime cost of diabetes, cost savings were even greater.[1]

These data build on previously reported real-world evidence which found that switching to Tresiba(R) from other basal insulins, mainly insulin glargine U100 and insulin detemir, provides significant reductions in blood glucose levels, as well as lowering the rates of potentially dangerous severe hypoglycaemic episodes by 92% in people with type 2 diabetes and by 85% in people with type 1 diabetes.[2][3]

"In addition to the body of evidence supporting its benefits in clinical practice, Tresiba(R) has been shown to be a cost-effective treatment option across various European healthcare systems," said Mads Krogsgaard Thomsen, executive vice president and chief science officer at Novo Nordisk. "We hope these encouraging findings from real-world clinical practice will help make Tresiba(R) available to even more people living with type 1 and type 2 diabetes around the world."

About the analysis

This new analysis was based on an Italian subpopulation of the EU-TREAT (EUropean TREsiba AudiT) study, which is a European, multicentre, real-world evidence study with 2,550 people, investigating the effect of switching to Tresiba(R) from another basal insulin in people with type 1 and type 2 diabetes.[1-3]

Cost-effectiveness was evaluated based on change in hypoglycaemia rates, basal and prandial insulin dose, and body weight at 6 months after switching to Tresiba(R) in 397 people with type 1 and 153 people with type 2 diabetes from Italy. Cost-effectiveness models evaluated the incremental cost-effectiveness ratio (ICER) for cost per quality-adjusted life year (QALY)[1] and enable comparisons to be made across treatments and therapy areas.

About Tresiba(R)

Tresiba(R) (insulin degludec) is a once-daily basal insulin that provides duration of action beyond 42 hours with a flat and stable glucose-lowering effect.[4],[5] It provides low variability in blood glucose levels and a lower risk of overall, nocturnal and severe hypoglycaemia vs. insulin glargine U100.[4],[6] On occasions when administration at the same time of day is not possible, Tresiba(R) allows for flexibility in day-to-day dosing time with a minimum of eight hours between injections.[4] Tresiba(R) received its first regulatory approval in September 2012 and has since been approved in more than 80 countries globally. It is now commercially available in more than 50 countries.

About Novo Nordisk

Novo Nordisk is a global healthcare company with more than 90 years of innovation and leadership in diabetes care. This heritage has given us experience and capabilities that also enable us to help people defeat obesity, haemophilia, growth disorders and other serious chronic conditions. Headquartered in Denmark, Novo Nordisk employs approximately 41,700 people in 77 countries, and markets its products in more than 165 countries. Novo Nordisk's B shares are listed on Nasdaq Copenhagen (Novo-B). Its ADRs are listed on the New York Stock Exchange (NVO). For more information, visit www.novonordisk.com , Facebook , Twitter , LinkedIn , YouTube .

Further information
References

1. Haldrup S, Lapolla A, Gundgaard J, et al. Cost-effectiveness of switching to insulin degludec (ideg) in real-world clinical practice in italy. Poster presentation. International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 20th Annual European Congress, Glasgow, Scotland. November 2017.

2. Siegmund T, Tentolouris N, Knudsen TS, et al. EU-TREAT 1: Switching to insulin degludec reduces the risk of hypoglycaemia in patients with T1DM in a real-world setting. Poster presentation. 77th Annual Scientific Sessions of the American Diabetes Asosciation (ADA), San Diego, California, US. June 2017.

3. Schultes B, Tentolouris N, Knudsen TS, et al. EU-TREAT 2: Switching to insulin degludec improves glycaemic control in patients with T2DM in a real-world setting. Poster presentation. 77th Annual Scientific Sessions of the American Diabetes Asosciation (ADA), San Diego, California, US. June 2017.

4. EMA. Tresiba(R) Summary of Product Characteristics. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002498/WC500138940.pdf . Last accessed: October 2017.
5. Haahr H, Heise T. A review of the pharmacological properties of insulin degludec and their clinical relevance. Clin Pharmacokinet. 2014; 53:787-800.
6. Marso SP, McGuire DK, Zinman B, et al. Efficacy and safety of degludec versus glargine in type 2 diabetes. N Engl J Med. 2017; 377:723-732.
Novo Nordisk A/S
Corporate Affairs
Novo Alle
2880 Bagsvaerd
Denmark
Telephone:
+45-4444-8888
Internet:
www.novonordisk.com
CVR no:
24 25 67 90
ZINC#: HQMMA/TB/1017/0371 November 2017
Further information
Media:
Katrine Sperling
+45-4442-6718
krsp@novonordisk.com
Asa Josefsson
+45-3079-7708
aajf@novonordisk.com
Investors:
Peter Hugreffe Ankersen
+45-3075-9085
phak@novonordisk.com
Hanna Ogren
+45-3079-8519
haoe@novonordisk.com
Anders Mikkelsen
+45-3079-4461
armk@novonordisk.com
Christina Kjær
+45-3079-3009
cnje@novonordisk.com
Kasper Veje (US)
+1-609-235-8567
kpvj@novonordisk.com
Source: Novo Nordisk

Latest Press Release

Merck Announces FDA Orphan Drug Designation for Bifunctional Immunotherapy M7824 in Biliary Tract Cancer

- FDA grants M7824, an investigational bifunctional immunotherapy, orphan drug designation in biliary tract cancer - First regulatory designation for M7824 following recent presentation of first clinical data in BTC - BTC is a group of rare, aggressive...

Merck in Agreement With Cyclica for AI-augmented Screening Platform to Expand Research Capabilities

- Agreement to screen discovery and early development compounds using artificial intelligence and computational biophysics - Cloud-based in silico platform that screens small molecules to determine polypharmacological profiles - Evaluation to include...

Vitality-linked Insurers to Get 100 million People 20% More Active by 2025

Building on the results of the largest behaviour change study on physical activity, Vitality and its global network of insurers have collectively committed to improving the health of millions over the next seven years. This is in line with the World...

World Congress of Cardiology Cardiovascular Health 2018 Opens in Dubai

- Professor David Wood, President of the World Heart Federation, welcomes more than 5000 cardiologists, doctors, nurses, and health and policy experts from around the world to Dubai for WCC 2018 at a time when the opportunities for a sustainable impact...

Data Presented at 2nd Healthy Lung Summit 2018 to Demonstrate Impact of AstraZeneca#s Healthy Lung Partnership Programme

Deepening commitment to drive improvements for patients with respiratory disease across Asia, AstraZeneca with Business Sweden, The Swedish Trade & Invest Council in Taiwan, hosts the second Healthy Lung Summit, ahead of the 2018 Asia Pacific Society...

Related Topics