Menarini Ricerche to Present the Study Design of CD205-Shuttle, a First-in-human Trial of MEN1309/OBT076, at the ASCO Annual Meeting 2018

Food and Healthcare Press Releases Friday June 1, 2018 16:48
POMEZIA, Italy--1 Jun--PRNewswire/InfoQuest

Menarini Ricerche (Menarini Group) will present at ASCO Annual Meeting 2018 the study design of CD205-Shuttle, a multicenter first-in-human clinical study to evaluate MEN1309/OBT076, an antibody drug conjugate (ADC) investigated for the treatment of metastatic solid tumors and non-Hodgkin's lymphoma (NHL).

(Logo: http://mma.prnewswire.com/media/520214/Menarini_Ricerche_Logo.jpg )
(Logo: https://mma.prnewswire.com/media/699671/CD205_Shuttle_Logo.jpg )

MEN1309/OBT076 is a fully humanized IgG1 monoclonal antibody, in co-development with Oxford BioTherapeutics (OBT), conjugated to a potent cytotoxic maytansinoid toxin via a cleavable linker. The ADC is directed against a type I transmembrane glycoprotein CD205/Ly75, that is over-expressed in several solid tumors and NHL.

The poster "CD205-Shuttle study: A first-in-human trial of MEN1309/OBT076 an ADC targeting CD205 in solid tumor and NHL" focused on the innovative design of the dose-escalation study will be presented during the session "Developmental Therapeutics-Clinical Pharmacology and Experimental Therapeutics" Abstract no. TPS2606, on June 4, 2018 between 8:00 AM-11:30 AM at the McCormick Place Convention Center in Chicago, Illinois.

The CD205-Shuttle study is ongoing in major European oncology centers in Italy, Spain, Belgium and the UK. The study investigated to date 5 dose levels. The sixth dose level is currently being evaluated.
About the Menarini Group

The Menarini Group, with its headquarters in Florence, is present in 136 countries around the world with 17,000 employees. With a turnover of 3.6 billion Euro, Menarini today is 13th in Europe out of 5,345 companies and 35th worldwide out of 21,587 (source: IQVIA). Menarini has 6 Research & Development centres and its products are present in the most important therapeutic areas including cardiology, gastroenterology, pneumology, infectious diseases, diabetology, inflammation, and analgesics. Menarini's products are manufactured in the Group's 16 production sites, in Italy and abroad, where more than 583 million packs are produced and distributed over five continents each year. Through its pharmaceutical products, Menarini contributes continuously and with the highest quality standards towards the health of patients all around the world.

The Menarini Group has always pursued two strategic objectives: research and internationalization, and has a strong commitment to oncology research and development. As part of such commitment to oncology, Menarini, is developing four investigational new oncological drugs. Two of them are biologics, namely the anti-CD157 antibody MEN1112, and the toxin-conjugated, anti-CD205 antibody MEN1309. In addition, Menarini has recently added two small molecules to its oncology pipeline, the dual PIM and FLT3 kinase inhibitor MEN1703, and the PI3K inhibitor MEN1611, in clinical development for the treatment of a variety of hematological and/or solid tumors.

For further information please visit http://www.menarini.com
Source: Menarini Ricerche

Latest Press Release

Merck Awarded Australian CRISPR Nickase Patent for Foundational Genome-Editing Technology

- Patent covers paired Cas9 nickase technology to reduce off-target effects, advance gene therapy and research - Expands company's foundational CRISPR cutting and integration IP necessary to correct genetic defects in gene therapy patients - Merck to...

Kaneka officially starts continuous manufacturing under GMP

Kaneka Corporation (Headquarters: Minato-ku, Tokyo; President: Mamoru Kadokura) have installed continuous manufacturing equipment to be applied to pharmaceutical products at Kaneka Singapore Co. (Pte.) Ltd, (Headquarters: Singapore; President: Kazuhiko...

TIENS Group opens new high-tech Experience Store in Shenzhen

TIENS Group, one of leading corporations in the Healthcare industry, unveiled a new high-tech Customer Experience Store in Shenzhen. Li Jinyuan, founder and chairman of TIENS group, announced the official opening of its first store in the world on August...

Sotera Health#s Nordion completes the sale of its medical isotopes business to BWXT

- Nordion's increased focus on gamma technologies supports Sotera Health's company-wide commitment to Safeguarding Global Health(TM) Sotera Health LLC, the world's leading, fully integrated protector of global health, today announced the closing of the...

Menarini Ricerche to Sponsor Cancer Trial in Acute Myeloid Leukemia in USA

Menarini Ricerche, a company of the Menarini Group, announced today that the sponsorship of the ongoing Phase I/II study that is investigating MEN1703/SEL24 for the treatment of patients with relapsed/refractory (R/R) AML in the USA has been transferred...

Related Topics