Immune Advisors Publishes Peer-Reviewed Study Demonstrating Efficacy of a Probiotic and Digestive Enzymes Supplement in Protecting Against Side Effects of Cancer Chemotherapy

Food and Healthcare Press Releases Thursday August 2, 2018 08:09
SAN DIEGO--2 Aug--PRNewswire/InfoQuest
Immunotherapy Focused Consulting Company Provides Independent Support of the Value of Daily Body Restore (R)   for Cancer Patients

Immune Advisors, LLC, a California-based company focused on forming, financing, and growing companies in the immunotherapy and regenerative medicine space, announced today publication of a manuscript entitled "Protection from chemotherapy- and antibiotic-mediated dysbiosis of the gut microbiota by a probiotic with digestive enzymes supplement."   The paper was published in the peer-reviewed cancer focused journal, Oncotarget. Billionaire philanthropist, John Paul DeJoria, Co-Founder of Paul Mitchell Hair Care Products, stated: "As an investor in Daily Body Restore(R), I am very proud of the results and the study speaks for itself."

This article was authored by Thomas Ichim, Ph.D. of Immune Advisors, LLC in collaboration with Dr. Santosh Kesari, MD Ph.D. of the Pacific Neuroscience Institute and the John Wayne Cancer Institute, and Kim Shafer of Daily Body Restore(R), LLC, the developer of the supplement evaluated in the study.

The published results demonstrate that a commercially available supplement, Daily Body Restore (DBR)(R), which combines nine strains of probiotics and ten digestive enzymes, provides benefits in counteracting the adverse effects of a chemotherapeutic agent, 5-fluorouracil (5-FU), and an antibiotic, vancomycin, on the gut microbiome. Using an in vitro model comprising bioreactors that simulate conditions in the various compartments of the intestinal tract, DBR(R) was added at in vivo doses and the composition and activity of gut bacteria was evaluated. "This study implemented a very powerful in vitro model of the intestinal microbiome in which to evaluate the effects of the probiotic with digestive enzymes supplement," stated Dr. Massimo Marzorati, founder of ProDigest, the Belgian Company who conducted the in vitro testing of gut dysbiosis used in the publication. "The supplement was able to improve the numbers and activity of the microbial communities that were adversely impacted by the chemotherapeutic agent and the antibiotic."

The article can be accessed at: https://doi.org/10.18632/oncotarget.25778

It is known that chemotherapy drugs that are routinely administered to cancer patients can negatively impact the microbiome, which, in turn, is believed to diminish the efficacy of immunotherapy based cancer treatments and causes adverse events such as gastrointestinal side effects [1], [2].

Thomas E. Ichim, Ph.D., first author of the publication, co-founder and managing partner of Immune Advisors, LLC commented, "In recent years, there has been a growing awareness in the medical and scientific communities that the composition of bacteria in the gut is intricately involved in shaping the immune system and drug responsiveness. The data recently published today, in my opinion, strongly support the viability of administering Daily Body Restore(R) to patients who are being treated with chemotherapy."

Contact: Thomas Ichim, Ph.D., Managing Partner, Immune Advisors, LLC, thomas.ichim@gmail.com , 858 353 0309
[1] Routy et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 2018 Jan 5;359(6371):91-97. http://science.sciencemag.org/content/359/6371/91.long
[2] Alexander et al. Gut microbiota modulation of chemotherapy efficacy and toxicity. Nat Rev Gastroenterol Hepatol. 2017 Jun 14(6):356-365. https://www.nature.com/articles/nrgastro.2017.20

Latest Press Release

Grunenthal Acquires Averitas Pharma and Establishes Commercial Footprint in the US

Grunenthal announced today that it has acquired the US-based pharmaceutical company Averitas Pharma, thereby extending its commercial footprint to the United States. Averitas Pharma will be commercialising the pain patch Qutenza(R) (8 % capsaicin) for...

Ascensia Diabetes Care Highlights the Support That Families Provide for People With Diabetes To Mark World Diabetes Day 2018

Today, Ascensia Diabetes Care, a global leading diabetes care company, launched their campaign for World Diabetes Day 2018 to celebrate the important role of families for people with diabetes. They are publishing 38 online artworks that tell the stories...

Qatar Foundation Ushers in New Era of Healthcare With Official Inauguration of Sidra Medicine

Her Highness Sheikha Moza bint Nasser, Chairperson of Qatar Foundation (QF), today officially inaugurated Sidra Medicine - a brand new, world-leading women's and children's hospital in Qatar. The grand opening reflects the country's broader focus and...

Singapore National Eye Centre, Singapore Eye Research Institute And Johnson Johnson Vision Set Sights On Halting Global Myopia Epidemic

New US$26.35 Million Collaboration Seeks Prevention and Treatment Solutions to Address Rising Burden of Condition The Singapore National Eye Centre (SNEC), the Singapore Eye Research Institute (SERI) and Johnson & Johnson Vision today announced a...

TIENS Group Launches Global Expansion Into New Retail

Leading healthcare company, TIENS Group, has announced their global expansion into the new retail market with the opening of a new flagship TIENS Experience Store in China. Located in the TIENS International Health Industrial Park, the new store features...

Related Topics